![]() ![]() Since MTHFR mutations affect the way the body processes certain vitamins, one of the important ways of handling the condition is nutritional supplementation. The risk of developing the conditions depends on the type of MTHFR mutation present. ![]() The risk of developing certain types of cancer.Anxiety, depressive disorder, and other mental health conditions.These may lead to various health conditions, including the following. MTHFR mutations may cause B complex and other nutritional deficiencies. Health Conditions Associated With MTHFR Mutations While the MTHFR mutation doesn’t directly lead to vitamin B6 (pyridoxine) deficiency, there may be connections between these two.Ī 2016 study reports that pyridoxine may help better recycle folate in the body and improve folic acid metabolism.Īs a result, vitamin B6 may bring down the buildup of unmetabolized serum folic acid levels. As a result, folate deficiency can, in turn, lead to vitamin B12 deficiency. ![]() Vitamin B12 requires the active form of folate to be absorbed by the body. So, people with MTHFR mutations may have folate or vitamin B9 deficiency. MTHFR mutations affect the ability of the body to convert folate into its usable form. How Do MTHFR Mutations Affect Vitamin Requirements? People carrying the TT genotype of this SNP may have significantly high levels of homocysteine and lower levels of serum folate.Īccording to studies, about 25% of Hispanics and 10-15% of Caucasians in North America are born to have the TT genotype of this SNP and have an increased risk of developing MTHFR deficiency. One commonly noted Single Nucleotide Polymorphism (SNP) in the MTHFR gene is rs1801133. People with MTHFR gene mutations may have high levels of homocysteine and low serum folate levels. This condition is caused by low levels of MTHFR enzymes in the body due to impaired functioning of the MTHFR gene. Certain variations in the MTHFR gene can lead to MTHFR deficiency. ![]()
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